​Background and objectives: Health-related quality of life encompasses the perception of valued characteristics of health such as well being and a feeling of comfort. The purpose of this study was to investigate the effect of individuals’ physical activity level on their quality of life.

Material and Methods: This was a descriptive-analytic study. The studied sample consisted of 404 high school boys and girls of the district 1 of Qom city. The tools used in the research included self-administered questionnaire regarding quality of life, the process of changing physical activity and demographic variables. SPSS18, ANOVA test and descriptive statistics were applied for analysis.

Results: In this study, regarding the stages of change for physical activity, 41.2% of the students were in the pre-contemplation and contemplation stages, in which this variable showed a significant correlation with students’ quality of life. More physically active individuals had a better quality of life (p <0.05).  Father's occupation and mother's education also had a significant correlation with quality of life (p <0.05).

Conclusion: To make a decision for doing physical activity and to do exercises, have positive and decisive impact on health-related quality of life; therefore, it is recommended that necessary trainings are given to students to modify and strengthen their attitudes toward physical activity. Also, sport facilities should be provided in natural environments through government-organized planning.