​Background and Objectives: Breast cancer is one of the most common cancers among women that early diagnosis greatly increases the chance of recovery. Self-examination is one of the ways for screening and early detection of breast cancer. The aim of this study was to determine the knowledge, attitude and practice of women employed in the Khalkhal Faculty of Medical Sciences towards breast self-examination (BSE) and its relationship with some individual characteristics.

Material and Methods: This study cross-sectional study was conducted on 300 women who were employed in Khalkhal Faculty of Medical Sciences. A researcher-made questionnaire designed in four categories was used which contained demographic and questions related to the knowledge, attitude and performance. Data were analyzed using SPSS v. 13 software.

Results: The level of knowledge, attitude and practice of BSE among the majority of women was partially favorable (5/56, 6/53 and 70/84 percent, respectively). Knowledge, attitudes and practices of women about BSE was affected by their field of study (P<0.001).

Conclusion: Women working in Khalkhal Faculty of Medical Sciences have relatively good level of knowledge, attitude and practice about BSE but with regard to the role of health workers in education and improving health; it is recommended to implement programs to achieve an ideal level regarding the knowledge, attitude and performance.