The Life style promotion project (LPP) is a long term community-based project for prevention and control of non-communicable diseases (NCDs). The design consisted of two stages; phase I was a cross-sectional prevalence study of NCDs and the associ¬ated risk factors. Phase II is a prospective follow-up study in which data recollection will be performed every 2 years after the intervention initiated. In this study, 1,500 households residing in Tabriz, Marand, Bonab, Oskoo, Varzeghan, Khodafrin (150 clusters of 10 households) cities which in terms of socio-economic variables, distance from the center, population and access to medical facilities are in the same category of other cities of province will be examined. A total of 3000 patients (15-65 years) living in East Azerbaijan province will be randomly enrolled. After obtaining informed consent from all participants, weight, height, waist circumference, hip circumference and blood pressure will be measured with standard tools. Fasting blood sugar, total cholesterol, LDL-C, HDL-C, TG, serum vitamin D, ALT, AST, Hb and serum ferritin will be assessed. The questionnaires related to socioeconomic status, dietary intake, physical activity, angina (Rose), asthma, anxiety, smoking, food security and safety will be completed. Necessary data in other variables such as age, gender, menopausal status, medical history and medication use will be collected using questionnaires. The results of this study can be used in formulating long term health programs for the prevention of non-communicable diseases.